Successful Treatment of Herpes Esophagitis With Ganciclovir in a Liver Transplant Patient
Abstract
The presence of Herpes Simplex Virüs-1 (HSV-1) esophagitis in patients with liver transplantation has been reported rarely. Among the reports that are accessible in the literature, none could have shown tissue positivity for Herpes virus-1 DNA via Polymerase Chain Reaction (PCR) in patients with liver transplantation. This case is presented as the patient was diagnosed with herpes esophagitis based on the histopathological findings and HSV-1 DNA positivity (detected by PCR) in the biopsy material and was treated with Ganciclovir. Due to the specific action of Ganciclovir against CMV infections, it is natural that the drug cannot use in the treatment of HSV infections. However it is reported that ganciclovir has been reduced the incidence of symptomatic HSV infections after liver transplantation. We report on a patient after liver transplantation with HSV-1 esophagitis, who was successfully treated with Ganciclovir. We assume that most transplant centers according to their protocols use ganciclovir for CMV prophylaxis, which may contribute to avoid HSV infection.
Keywords
Full Text:
PDFReferences
Matevossion, E., Doll, D., Weirich, G., Burian, M., Knebel, C., & Thorban, S., et al. (2008). Seronegative herpes simplex associated esophagogastric ulcer after liver transplantation. Case Rep Gastroenterol, 2, 103-108.
Kang, Y. N., Oh, H. K., Chang, Y. C., Kim, H. C., Lee, S. L., & Hwang, M., et al. (2006). Systemic herpes simplex virus infection following cadaveric renal transplantation: A case report. Transplant Proc., 38(5), 1346-7.
Ahn, B. M., Chung, H. U., Kim, S. Y., Shin, W. S., Lee, B. S., & Chung, K. W., et al. (1994). Acute herpetic esophagitis—A case report. Korean J Intern Med, 9(2), 120-4.
Shiffer, J. T., & Corey, L. (2010). Herpes simplex virus. In G. L. Mandell, J. E. Bennett, & R. Dolin (Eds.). Principles and practice of infectious diseases (7th ed., pp.1943-62). Philedelphia: Churchıll Livingstone.
Gane, E., Saliba, F., & Valdecasas, G. J., et al. (1997). Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients. The oral ganciclovir international transplantation study group. Lancet, 350(9093), 1729-33.
Stránská, R., Schuurman, R., de Vos, M., & van Loon, A. M. (2004). Routine use of a highly automated and internally controlled real-time PCR assay for the diagnosis of Herpes simplex and Varicella-zoster virus infections. Journal of Clinical Virology, 30, 39-44.
Aoki, F. Y., Hayden, F. G., & Dolin, R. (2010). Antiviral drugs (other than antiretroviral). In G. L. Mandell, J. E. Bennett, & R. Dolin (Eds.), Principles and practice of infectious diseases (7th ed., pp.565-611). Philedelphia: Churchıll Livingstone.
DOI: http://dx.doi.org/10.3968/gh.v2i1.4419
Refbacks
- There are currently no refbacks.
Copyright (c) 2015
Reminder
If you have already registered in Journal A and plan to submit article(s) to Journal B, please click the CATEGORIES, or JOURNALS A-Z on the right side of the "HOME".
We only use three mailboxes as follows to deal with issues about paper acceptance, payment and submission of electronic versions of our journals to databases:
caooc@hotmail.com; gh@cscanada.net; gh@cscanada.org
Articles published in Gastroenterology and Hepatology are licensed under Creative Commons Attribution 4.0 (CC-BY).
GASTROENTEROLOGY AND HEPATOLOGY Editorial office
Address: 1055 Rue Lucien-L'Allier, Unit #772, Montreal, QC H3G 3C4, Canada.
Telephone: 1-514-558 6138
Website: Http://www.cscanada.net Http://www.cscanada.org
E-mail:gh@cscanada.net, gh@cscanada.org
Copyright © 2010 Canadian Research & Development Centre of Sciences and Cultures