Synthesis, Characterization and Preliminary Microbial Studies of 4-{[(E)–1h–Indol–3h–Lmethylidene]Amino}–1,5-Dimethyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol–3-One and Its Al(Iii), In(Iii) and Tl(I) Complexes
Abstract
4-{[(E)–1H–indol–3H–ylmethylidene]amino}–1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol–3-one and its Al(III), In(III) and Tl(I) Complexes have been synthesized and characterized by physical methods and spectral studies. All the complexes were purified and their structures were elucidated using melting point, stoichiometry, molar conductivity, UV-visible, infrared, nuclear magnetic resonance and GCMS Spectral Studies The geometry around the metals were deduced based on the spectral information and were found to be five coordinate in all the complexes. The Schiff base ligand is coordinated to the metals through the participation of its imine nitrogen, indole-nitrogen and the oxygen of the antipyrine moiety. These complexes were also tested against different bacteria and fungi using Agar well diffusion method to determine their antimicrobial potency and they were found sensitive against Escherichia Coli, Pseudomonas aeruginosa, Basillus subtilis and Candida albicans but none was found active against Staphylococcus aureus.
Keywords
Full Text:
PDFReferences
Andrea, T. (1897/2009). Notes from Schiff‘s lessons (1 & 2). Retrieved from http: // en. Wikipedia. Org/wiki/Hugo: Schiff
Dedley, H. Y., & Ian, F. (1980). Spectroscopic methods in organic chemistry (3rd ed., pp.1-74). McGraw-Hill book Company UK Limited.
El-Saied, F. A., Ayad, M. L., Issa, R. M., & Aly, S. A. (2001). Synth. And characterization of Iron(III), Cobalt(II), Nickel(II) and Copper(II) Complexes of 4-Formylazohydrazo aniline antipyrine. Polish J. Chem., 75, 773-783.
Hamid, L. S., Amjid, I., Saeed, A., & George, W. W. (2006). Molecules (5th ed., 1 & 2, p.205). Interscience Publishers, Inc. New York.
Hishashi, O., Sigeo, K., Yoneichiro, M., Tadashi, T., Tomoko, T., Mitsunori, T., & Yasuomi, N. (1972-1976). Binuclear metal complexes IV, IX, VI, XV. In Bulletin of the chemical Society of Japan, 45, 47 (7), 46 (9) 2480, 1669, 1462, 2469 respectively.
Prasadd, R. N., Agrawal, M., & Sharma, M. (2002). J. Serb. Chem, 67(4), 229.
Radmarkvishnan, T., Joseph, P.T., & Prabhakaran, C. (1976). Inorg. Nucl. Chem., 38, 2217.
Ramesh, R., Suganthy, P. K., & Nakaranjan, K. (1996). Synth. React. Inorg. Met-org. Chem., 26, 47.
Shane, G. T., Tomohiro, S., Takunor, H., Reiko, K., Julie, L., & Daniel, B. L. (2004). Inorganic chemistry, 43(20), 6168-6176.
Shankar, G., Premkumar, R .R., & Ramalingam, S. K. (1986). Tetrahedron, 5(4), 991.
Wang, C. L., Wang, Y. L., Wang, X.Y. (1999). J. Chin. Chem. Soc., 46(4), 577.
DOI: http://dx.doi.org/10.3968/8519
DOI (PDF): http://dx.doi.org/10.3968/%25x
Refbacks
- There are currently no refbacks.
Copyright (c) 2016 Advances in Natural Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
Reminder
We are currently accepting submissions via email only.
The registration and online submission functions have been disabled.
Please send your manuscripts to ans@cscanada.net,or ans@cscanada.org for consideration. We look forward to receiving your work.
Articles published in Advances in Natural Science are licensed under Creative Commons Attribution 4.0 (CC-BY).
ADVANCES IN NATURAL SCIENCE Editorial Office
Address: 1055 Rue Lucien-L'Allier, Unit #772, Montreal, QC H3G 3C4, Canada.
Telephone: 1-514-558 6138
Website: Http://www.cscanada.net; Http://www.cscanada.org
E-mail:caooc@hotmail.com; office@cscanada.net
Copyright © 2010 Canadian Research & Development Centre of Sciences and Cultures